Yacht Life Sciences has a vacancy for an Assistant Scientist - Downstream Process Development (DSP) at our client Janssen Vaccines & Prevention in Leiden.
For the Bacterial Vaccines department we are recruiting an Assistant Scientist to join the Downstream Process Development (DSP) team. The successful candidate will be part of a dynamic team driving research-scale production and characterization of bacterial vaccine candidates, mainly consisting of protein- and glycoprotein antigens. To this end, the DSP team develops and characterizes a broad range of biopharmaceutical DSP units using, amongst others, high-throughput process development methodologies and develops end-to-end purification processes at different scales. These newly developed purification processes are used for producing research-grade material for preclinical evaluation and are transferred to early process development partners.
As an Assistant Scientist DSP, you will support the Downstream Process Development team in performing purification experiments and in-process monitoring assays to facilitate early-stage bacterial vaccine development.
Your main responsibilities will be:
- Supporting and executing purification and filtration experiments
- Preparation and execution of (high throughput) in-process monitoring assays
- Transferring in-process monitoring assays (plate based) to high-throughput platforms
- Performing (preliminary) data analysis, reporting and presentation of the main conclusions to the DSP team
- Experimental documentation in an electronic laboratory notebook (ELN)
- Preparation of process documentation, including work instructions and batch records
- Handling laboratory stocks and keeping inventories up to date.
- Keeping track of equipment status and/or maintenance.
- Keeping systems in place for inventory/tracking of samples and process intermediates.
- Following safety procedures, contribute to the maintenance of clean laboratory environment
- Bachelor degree in a relevant field such as Biochemistry, Bacteriology, Biotechnology, Biological Engineering or related fields (candidates with a Master degree will not be considered for this position).
- >2 years’ relevant experience or relevant internships
- Experience with protein and/or glycoprotein purification (DSP) methodologies
- Understanding of analytical techniques to analyze proteins (e.g. plate-based colorimetric assays, capillary electrophoresis, ELISA, Western blotting, BLI, SDS-PAGE, UPLC-based techniques).
- Knowledge of high-throughput platforms and liquid handling systems
- Relevant software skills (e.g. Unicorn, MS Office, databases, sample management)
- Nice to have: programming skills
- A fluency in English
- Flexible and creative team player
- Communicates clearly and efficiently
- Is organized and methodic in data generation and handling (e.g. security and integrity)
We offer a challenging position which allows you to work in a dynamic and international environment, ensuring diversity in your work and creating plenty of opportunities for personal development. This concerns a full-time secondment contract for 1 year .
We will offer a competitive benefits package in line with the seniority of the position (salary between 2600 and 3200 euro gross per month). You will become a member of a strong professional network who shares your education, ambitions and competencies. This will enable you to interact with your colleagues and become a member of the YACHT network, which stretches the Life Science industry. You will be challenged by your peers and will be able to follow courses and training via our Yacht Academy and keep your knowledge and skills up-to-date: boosting your career through personal and scientific growth.
Janssen Vaccines is committed to developing first-in-class or best-in-class vaccines for some of the world’s most life-threatening infectious diseases. They have built a dedicated, world-class, multi-functional team across a variety of disciplines to develop a promising vaccines pipeline.
The Bacterial Vaccines department is working on the discovery- and early development of novel vaccines for bacterial infectious diseases. We strive to address unmet medical needs, such as bacteremia (sepsis) and nosocomial infections. Projects at the Bacterial Vaccines department are primarily structured on scientific- and technical collaboration with external biotechnology partners (governmental and industrial) that are innovative leaders in their field. This working process includes ‘state of the art’ vaccine discovery, with subsequent in vivo evaluation of these vaccine candidates in animal models for immunogenicity and/or efficacy. In addition, manufacturing processes are optimized and established, and the resulting clinical trial material is evaluated in human clinical studies.
Inclusiviteit en diversiteit
Uiteraard staat deze vacature open voor iedereen die zich hierin herkent. We geloven dat diverse teams van belang zijn voor ons als lerende organisatie, die voorop wil blijven lopen in de wereld van werk. Want juist verschillen tussen mensen zorgen voor groei. Van collega's, klanten, kandidaten en daarmee van Yacht. Heb jij een uniek talent? We ontmoeten je graag.